Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice

The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, this context, the improvement effects young Asian pear (Pyrus pyrifolia Nakai) extracts have not been evaluated yet. Thus, study investigated anti-inflammatory and lung damage immature extract (IAP; 400, 200, 100 mg/kg) using a particulate matter 2.5 μm (PM2.5)-induced sub-acute injury mouse model. experimental results were compared with dexamethasone (0.75 mg/kg), used as control drug. After two intranasal instillations PM2.5 ten doses IAP for eight days, changes macroscopic autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, antioxidant defense system, histopathology, mRNA expression tissue confirmed. Stress-induced inflammatory through increased PM2.5-induced PI3K/Akt p38 MAPK was significantly suppressed via administration (400–100 mg/kg). Furthermore, promoted serous fluid production tissue, substance P ACh levels, decreased mucus-production-related MUC5AC MUC5B mRNA. Interestingly, observed showed dose-dependent manner without serious hepatotoxicity. indicate that proper oral could be helpful protecting against diseases, positioning potential candidate an alternative agent to safeguard respiratory system.